5.
(11) Patent number: 2143900
(46) Date of publication: 10.01.2000
(51) Int. Cl.7: A 61 K 31/455, 47/48
(21) Application number: 99106725/14
(22) Application date: 31.03.1999
(71) Applicant:
Institut tsitologii i genetiki SO RAN
(72) Inventor:
Shkurupij V.A.,
Kurunov Ju.N.,
Grishin O.V.,
Troitskij A.V.,
Bogdanova L.A.,
Guljaeva E.P.
(73) Proprietor:
Institut tsitologii i genetiki SO RAN
(98) Mail address:
630090, Novosibirsk, pr-t Lavrent'eva, 10, ITs i G SO RAN, patentnyj otde
(54) METHOD OF PREPARING ISONIAZID WITH PROLONGED EFFECT
(57)
FIELD: pharmaceutical industry and pulmonology. SUBSTANCE: isoniazid is added to concentration 0.4 to 4.0% to dextran (for example, rheopolyglukin) activated by irradiation of deceleration gamma-emission in dose 2.5-3.5 Mrad. Mixture is heated to 100 C, kept at this temperature for 10-15 min, and cooled to room temperature. EFFECT: simplified procedure. 3 cl, 2 ex
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