Preface ........................................................ ix
Endocytosis: Past, Present, and Future .......................... 1
Sandra L. Schmid, Alexander Sorkin, and Marino Zerial
Molecular Structure, Function, and Dynamics of Clathrin-
Mediated Membrane Traffic ...................................... 11
Tom Kirchhausen, David Owen, and Stephen C. Harrison
Endocytic Accessory Factors and Regulation of Clathrin-
Mediated Endocytosis ........................................... 37
Christien J. Merrifield and Marko Kaksonen
Cargo Recognition in Clathrin-Mediated Endocytosis ............. 53
Linton M. Traub and Juan S. Bonifacino
Imaging and Modeling the Dynamics of Clathrin-Mediated
Endocytosis .................................................... 77
Marcel Mettlen and Gaudenz Danuser
Clathrin-lndependent Pathways of Endocytosis ................... 93
Satyajit Mayor, Robert G. Parton, and Julie G. Donaldson
The Complex Ultrastructure of the Endolysosomal System ........ 113
Judith Klumperman and Graça Raposo
Rab Proteins and the Compartmentalization of the Endosomal
System ........................................................ 135
Angela Wandinger-Ness and Marino Zerial
Retromer: A Master Conductor of Endosome Sorting .............. 161
Christopher Burd and Peter J. Cullen
Lipid Sorting and Multivesicular Endosome Biogenesis .......... 175
Christin Bissig and Jean Gruenherg
Molecular Mechanisms of the Membrane Sculpting ESCRT Pathway .. 193
William Mike Henne, Harald Stenmark, and Scott D. Emr
Ubiquitin-Dependent Sorting in Endocytosis .................... 205
Robert C. Piper, Ivan Dikic, and Gergely Lukacs
The Biogenesis of Lysosomes and Lysosome-Related Organelles ... 227
J. Paul Luzio, Yvonne Hackmann, Nele M.G. Dieckmann, and
Gillian M. Griffiths
Bending "On the Rocks"—A Cocktail of Biophysical Modules to
Build Endocytic Rathways ...................................... 245
Ludger Johannes, Christian Wunder, and Patricia Bassereau
Function and Regulation of the Endosomal Fusion and Fission
Machineries ................................................... 263
Alexis Gautreau, Ksenia Oguievetskaia, and Christian
Ungertnann
Lysosomal Adaptation: How the Lysosome Responds to External
Cues .......................................................... 279
Carmine Settembre and Andrea Ballabio
Endocytosis and Autophagy: Exploitation or Cooperation? ....... 295
Sharon A. Tooze, Adi Abada, and Zvulun Elazar
The Cell Biology of the Endocytic System from an
Evolutionary Perspective ...................................... 311
Jeremy G. Wideman, Ka Fai Leung, Mark C. Field, and Joel
B. Backs
Unconventional Functions for Clathrin, ESCRTs, and Other
Endocytic Regulators in the Cytoskeleton, Cell Cycle,
Nucleus, and Beyond: Links to Human Disease ................... 323
Frances M. Brodsky, R. Thomas Sosa, Joel A. Ybe, and
Theresa J. O'Halloran
Reciprocal Regulation of Endocytosis and Metabolism ........... 339
Costin N. Antonescu, Timothy E. McGraw, and Amira Klip
Presynaptic Membrane Retrieval and Endosome Biology:
Defining Molecularly Heterogeneous Synaptic Vesicles .......... 359
Jennifer R. Morgan, Heather Skye Comstra, Max Cohen, and
Victor Faundez
Neuronal Signaling through Endocytosis ........................ 375
Katharina E. Cosker and Rosalind A. Segal
MHC Class II Antigen Presentation by Dendritic Cells
Regulated through Endosomal Sorting ........................... 391
Toine ten Broeke, Richard Wubbolts, and Willem Stoorvogel
Endocytosis, Signaling, and Beyond ............................ 413
Pier Paolo Di Fiore and Mark von Zastrow
Endocytosis and Signaling during Development .................. 427
Christian Bökel and Michael Brand
Cargo Sorting in the Endocytic Pathway: A Key Regulator
of Cell Polarity and Tissue Dynamics .......................... 443
Suzanne Eaton and Fernando Martin-Belmonte
The Role of Endocytosis during Morphogenetic Signaling ........ 461
Marcos Gonzalez-Gaitan and Frank Jülicher
Role of Endosomes and Lysosomes in Human Disease .............. 475
Frederick R. Maxfield
Endocytosis and Cancer ........................................ 491
Ira Meоlman and Yosef Yarden
Endocytosis of Viruses and Bacteria ........................... 515
Pascale Cossart and Art Helenius
Exploiting Endocytosis for Nanomedicines ...................... 543
Akin Akinc and Giuseppe Battaglia
tmaging the Dynamics of Endocytosis in Live Mammalian
Tissues ....................................................... 567
Roberto Weigert
Index ......................................................... 579
|