List of Figures ............................................... vii
List of Tables ................................................. xi
List of Contributors ......................................... xiii
Introduction .................................................... 1
PART I: ADVANCES IN GPCR PROTEIN RESEARCH
1 The evolution of the repertoire and structure of С
protein-coupled receptors .................................... 5
Torsten Schöneberg, Kristin Schröck, Claudia
Stäubert, and Andreas Russ
2 Functional studies of isolated CPCR-C protein complexes
in the membrane bilayer of lipoprotein particles ............ 32
Adam J. Kuszak, Xiao Jie Yao, Sören С. F. Rasmussen,
Brian К. Kobilka, and Roger K. Sunahara
PART II: OLIGOMERIZATION OF GPCRS
3 GPCR-G protein fusions: Use in functional dimerization
analysis .................................................... 53
Graeme Milligan
4 Time-resolved FRET approaches to study GPCR complexes ....... 67
Jean Phillipe Pin, Damien Maurel, Laetitia Comps-Agrar,
Carine Monnier, Marie-Laure Rives, Etienne Doumazane,
Philippe Rondard, Thierry Durroux, Laurent Prézeau, and
Erin Trinquet
5 Signaling of dopamine receptor homo- and heterooligomers .... 90
Ahmed Hasbi, Brian F. O'Dowd, and Susan R. George
6 Functional consequences of chemokine receptor
dimerization ............................................... 111
Mario Mellado, Carlos Martínez-A., and José Miguel
Rodríguez-Frade
PART III: GPCR SIGNALING FEATURES
7 G protein functions identified using genetic mouse
models ..................................................... 125
Stefan Offermanns
8 Kinetics of GPCR, G protein, and effector activation ....... 145
Peter Hein
9 RGS-RhoGEFs and other RGS multidomain proteins as
effector molecules in GPCR-dependent and GPCR-independent
cell signaling ............................................. 159
José Vázquez-Prado and J. Silvio Gutkind
10 Adenylyl cyclase isoform-specific signaling of GPCRs ....... 189
Karin F.К. Ejendal, Julie A. Przybyla, and Val J. Watts
11 G protein-independent and β arrestin-dependent GPCR
signaling .................................................. 217
Zhongzhen Nie and Yehia Daaka
12 Assays to read GPCR modulation and signaling ............... 231
Ralf Heilker and Michael Wolff
PART IV: LIGAND PHARMACOLOGY OF GPCRS
13 Assessing allosteric ligand-receptor interactions .......... 247
Ivan Toma Vranesic and Daniel Hoyer
14 7TM receptor functional selectivity ........................ 270
Terry Kenakin
PART V: PHYSIOLOGICAL FUNCTIONS AND DRUG TARGETING OF GPCRS
15 β-Adrenoceptors in cardiovascular and respiratory
diseases ................................................... 287
Michele Ciccarelli, J. Kurt Chuprun, and Walter J. Koch
16 Role of metabotropic glutamate receptors in CNS
disorders .................................................. 321
Richard M. O'Connor and John F. Cryan
17 S1P receptor agonists, a novel generation of
immunosuppressants ......................................... 380
Rosa López Almagro, Gema Tarrasón, and Nuria
Godessart
18 Wnt/Frizzled receptor signaling in osteoporosis ............ 398
Georges Rawadi
Index ......................................................... 415
Color plates follow page 32.
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