Feature Boxes ................................................ xiii
Preface ........................................................ xv
Acknowledgments .............................................. xvii
1 Inorganic Chemistry Basics ................................... 1
1.1 Crystal field theory .................................... 1
1.2 Molecular orbital theory ............................... 11
1.3 Absorption spectra of metal complexes .................. 16
1.4 Magnetic properties of metal complexes ................. 28
1.5 Reactions of metal complexes ........................... 29
Problems .................................................... 45
References .................................................. 47
Further reading ............................................. 47
2 Metallo-Drugs and Their Action .............................. 49
2.1 Introduction ........................................... 49
2.2 Proteins as targets for metallo-drugs .................. 49
2.3 DNA as a target for metallo-drugs ...................... 58
2.4 Reaction of metal complexes in the biological milieu ... 63
2.5 Evaluating the pharmacological effects of agents ....... 65
2.6 From discovery to the marketplace ...................... 67
Problems .................................................... 69
References .................................................. 70
Further reading ............................................. 71
3 Cisplatin ................................................... 73
3.1 Physical and chemical properties of cisplatin .......... 75
3.2 Formulation, administration and pharmacokinetics ....... 80
3.3 Reaction of cisplatin in biological media .............. 81
3.4 Uptake, cytotoxicity and resistance .................... 83
3.5 Interaction of cisplatin with cellular targets ......... 91
Problems ................................................... 101
References ................................................. 102
Further reading ............................................ 107
4 Platinum Anticancer Drugs .................................. 109
4.1 Carboplatin ........................................... 109
4.2 Oxaliplatin ........................................... 122
4.3 New platinum agents ................................... 134
Problems ................................................... 141
References ................................................. 143
Further reading ............................................ 147
5 Ruthenium, Titanium and Gallium for Treating Cancer ........ 149
5.1 Ruthenium compounds for treating cancer ............... 149
5.2 Titanium compounds for treating cancer ................ 167
5.3 Gallium for treating cancer ........................... 177
6 Gold Compounds for Treating Arthritis, Cancer and Other
Diseases ................................................... 191
6.1 Chemistry of gold in biological media ................. 191
6.2 Gold compounds for treating arthritis ................. 192
6.3 Gold complexes for treating cancer .................... 205
6.4 Gold complexes for treating AIDS and other diseases ... 210
Problems ................................................... 212
References ................................................. 214
Further reading ............................................ 217
7 Vanadium, Copper and Zinc in Medicine ...................... 219
7.1 Vanadium for treating diabetes ........................ 219
7.2 Role of copper and other metal ions in Alzheimer's
disease ............................................... 230
7.3 Copper in Wilson's and Menkes diseases ................ 235
7.4 Zinc-bicyclam: a chemokine receptor antagonist ........ 238
Problems ................................................... 242
References ................................................. 244
Further reading ............................................ 249
8 Metal Complexes for Diagnosing Disease ..................... 251
8.1 Technetium in diagnostic nuclear medicine ............. 252
8.2 Metal compounds as contrast agents for MRI ............ 263
Problems ................................................... 277
References ................................................. 279
Further reading ............................................ 282
9 Nanomedicine ............................................... 283
9.1 Nanoscience for treating disease ...................... 283
9.2 Nanomedicine in diagnosing disease .................... 295
9.3 Potential health risks of nanoparticles ............... 304
Problems ................................................... 306
References ................................................. 307
Further reading ............................................ 310
Index ......................................................... 311
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