Contributors ................................................... ix
Preface ...................................................... xvii
Acknowledgments ............................................... xix
SECTION I: INTRODUCTORY CHAPTERS
Chapter 1: Overview ............................................ 3
Shu Chien
Chapter 2: Perspectives of Biomechanics ....................... 13
Yuan-Cheng B. Fung and Wei Huang
SECTION II: CARDIOVASCULAR BIOENGINEERING
Chapter 3: Cardiac Electromechanics in the Healthy Heart ...... 37
Roy С.P. Kerckhoffs and Andrew D. McCulloch
Chapter 4: Cardiac Biomechanics and Disease ................... 53
Jeffrey H. Omens
Chapter 5: Bioengineering Solutions for the Treatment of
Heart Failure ...................................... 69
John T. Watson and Shu Chien
Chapter 6: Molecular Basis of Modulation of Vascular
Functions by Mechanical Forces ..................... 79
Shu Chien
Chapter 7: Autoregulation of Blood Flow: Examining the
Process of Scientific Discovery .................... 99
Paul С. Johnson
SECTION III: BLOOD CELL BIOENGINEERING
Chapter 8: Molecular Basis of Cell and Membrane Mechanics .... 117
Lanping Amy Sung
Chapter 9: Cell Activation in the Circulation: The Auto-
Digestion Hypothesis .............................. 131
Geert W. Schmid-Schönbein
Chapter 10: Blood Substitutes and the Design of Oxygen
Non-Carrying and Carrying Fluids .................. 149
Marcos Intaglietta
SECTION IV: RESPIRATORY-RENAL BIOENGINEERING
Chapter 11: Analysis of Human Pulmonary Circulation:
A Bioengineering Approach ......................... 163
Wei Huang, Michael R.T. Yen and Qinlian Zhou
Chapter 12: Pulmonary Gas Exchange ............................ 181
Peter D. Wagner
Chapter 13: Engineering Approaches to Understanding the
Kidney ............................................ 209
Scott C. Thomson
SECTION V: TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Chapter 14: Skeletal Muscle Tissue Bioengineering ............. 225
Richard L. Lieber and Samuel R. Ward
Chapter 15: Multi-Scale Biomechanics of Articular Cartilage ... 243
Won C. Bae and Robert L. Sah
Chapter 16: Design and Development of an In Vivo Force-
Sensing Knee Prosthesis ........................... 261
Darryl D.D'Lima and Peter C.Y. Chen
Chapter 17: The Implantable Glucose Sensor in Diabetes:
A Bioengineering Case Study ....................... 279
David A. Gough
Chapter 18: Stem Cells in Regenerative Medicine ............... 291
Shu Chien and Lawrence S. B. Goldstein
SECTION VI: NANOSCIENCE AND NANOTECHNOLOGY
Chapter 19: Engineering Compounds Targeted to Vascular Zip
Codes ............................................. 313
Erkki Ruoslahti
Chapter 20: The Structure of the Central Nervous System and
Nanoengineering Approaches for Studying and
Repairing It ...................................... 327
Gabriel A. Silva
Chapter 21: Cellular Biophotonics: Laser Scissors
(Ablation) ........................................ 353
Michael W. Berns
Chapter 22: Microelectronic Arrays: Applications from DNA
Hybridization Diagnostics to Directed Self-
Assembly Nanofabrication .......................... 369
Michael J. Heller and Dietrich Dehlinger
SECTION VII: GENOMIC ENGINEERING AND SYSTEMS BIOLOGY
Chapter 23: System's Biology: A Four-Step Process ............. 387
Jennifer L. Reed and Bernhard O. Palsson
Chapter 24: Bioinformatics and Systems Biology: Obtaining
the Design Principles of Living Systems ........... 401
Shankar Subramaniam
Chapter 25: Synthetic Biology: Bioengineering at the Genomic
Level ............................................. 427
Natalie Ostroff, Mike Ferry, Scott Cookson,
Tracy Johnson and Jeff Hasty
Chapter 26: Network Genomics .................................. 453
Trey Ideker
Chapter 27: Genomes, Genomic Technologies and Medicine ........ 473
Xiaohua Huang
SECTION VIII: SOCIO-ECONOMICAL ASPECTS OF BIOENGINEERING
Chapter 28: Ethics for Bioengineers ........................... 489
Michael Kalichman
Chapter 29: Opportunities and Challenges in Bioengineering
Entrepreneurship .................................. 507
Jen-Shih Lee
Chapter 30: How to Move Medical Devices from Bench to
Bedside ........................................... 507
Paul Citron
Index ......................................................... 533
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