Preface ........................................................ xi
list of Contributors ......................................... xiii
Acknowledgments ............................................... xix
1 Characterization of Nanomaterials for Toxicological
Evaluation ................................................... 1
Kevin W. Powers, Maria Palazuelos, Scott C. Brown and
Stephen M. Roberts
2 Criteria and Implementation of Physical and Chemical
Characteristics of Nanomaterials for Human Health Effects
and Ecological Toxicity Studies ............................. 29
Christie M. Sayes and David B. Warheit
3 Considerations for the Design of Toxicity Studies of
Inhaled Nanomedicines ....................................... 41
Lea Ann Dailey
4 High Aspect Ratio Nanoparticles and the Fibre
Pathogenicity Paradigm ...................................... 61
Craig A. Poland, Rodger Duffin and Ken Donaldson
5 Application of Zinc Oxide Quantum Dots in Food Safety ....... 81
Tony Jin, Dazhi Sun, Howard Zhang and Hung-Jue Sue
6 Evaluation of Nanotoxicity of Foods and Drugs: Biological
Properties of Red Elemental Selenium at Nano Size
(Nano-Se) In Vitro and In Vivo .............................. 97
Jinsong Zhang
7 Evaluation of Toxicity of Nanostructures in Biological
Systems .................................................... 115
Adam J. Gormley and Hamidreza Ghandehari
8 Developing Bioassay Methods for Evaluating Pulmonary
Hazards from Nanoscale or Fine Quartz/Titanium Dioxide
Particulate Materials ...................................... 161
David B. Warheit, Kenneth L. Reed and Christie
M. Sayes
9 Nanoparticles: Is Neurotoxicity a Concern? ................. 171
Jianyong Wang, Wenjun Sun and Syed F. Ali
10 Hepatotoxic Potential of Nanomaterials ..................... 183
Saura C. Sahu
11 Nanotoxicity in Blood: Effects of Engineered
Nanomaterials on Platelets ................................. 191
Jan Simak
12 Sources, Fate and Effects of Engineered Nanomaterials in
the Aquatic Environment .................................... 227
David S. Barber, Nancy D. Denslow, R. Joseph Griffitt
and Christopher J. Martyniuk
13 Nanotoxicity of Metal Oxide Nanoparticles in Vivo .......... 247
Weiyue Feng, Bing Wang and Yuliang Zhao
14 In Vivo Hypersensitive Pulmonary Disease Models for
Nanotoxicity ............................................... 271
Ken-ichiro Inoue and Hirohisa Takano
15 In Vivo and In Vitro Models for Nanotoxicology Testing ..... 279
Rosalba Gornati, Elena Papis, Mario Di Gioacchino,
Enrico Sabbioni, Isabella Dalle Donne, Aldo Milzani
and Giovanni Bernardini
16 In Vitro and In Vivo Toxicity Study of Nanoparticles ....... 303
Jayoung Jeong, Wan-Seob Cho, Seung Нее Kim and Myung-
Haing Cho
17 In Vitro and In Vivo Models for Nanotoxicity Testing ....... 335
Kyung O. Yu, Laura K. Braydich-Stolle, David
M. Mattie, John J. Schlager and Saber M. Hussain
18 In Vitro Models for Nanotoxicity Testing ................... 349
Yinfa Ma
19 In Vitro Human Lung Cell Culture Models to Study
the Toxic Potential of Nanoparticles ....................... 379
Fabian Blank, Peter Gehr and Barbara Rothen-
Rutishauser
20 Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence
and Mechanisms ............................................. 397
Thomas R. Pisanic, Sungho Jin and Veronica I. Shubayev
21 Toxicity Testing and Evaluation of Nanoparticles:
Challenges in Risk Assessment .............................. 327
David Y. Lai and Philip G. Sayre
11 Evaluating Strategies For Risk Assessment of
Nanomaterials .............................................. 459
Nastassja Lewinski, Huiguang Zhu and Rebekah Drezek
23 Strategies for Risk Assessment of Nanomaterials ............ 499
Hae-Seong Yoon, Hyun-Kyung Kim, Dong Deuk Jang and
Myung-Haing Cho
24 Metal Nanoparticle Health Risk Assessment .................. 519
Mario Di Gioacchino, Nicola Verna, Rosalba Gornati,
Enrico Sabbioni and Giovanni Bernardini
25 Application of Toxicology Studies in Assessing the Health
Risks of Nanomaterials in Consumer Products ................ 543
Joyce S. Tsuji, Fionna S. Mowat, Suresh Donthu and
Maureen Reitman
26 Safety Assessment of Engineered Nanomaterials in Direct
Food Additives and Food Contact Materials .................. 581
Penelope A. Rice, Kimberly S. Cassidy, Jeremy Mihalov
and T. Scott Thurmond
Index ......................................................... 597
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