PERSPECTIVES, David Julius, Editor
A Conversation with Rita Levi-Montalcini
Moses V. Chao ................................................ 1
CARDIOVASCULAR PHYSIOLOGY
Jeffrey Robbins, Section Editor
Protein Conformation-Based Disease: Getting to the Heart of
the Matter
David Terrell and Jeffrey Robbins ........................... 15
Cell Death in the Pathogenesis of Heart Disease: Mechanisms
and Significance
Russell S. Whelan, Vladimir Kaplinskiy, and Richard
N. Kitsis ................................................... 19
Autophagy During Cardiac Stress: Joys and Frustrations of
Autophagy
Roberta A. Gottlieb and Robert M. Mentzer, Jr. .............. 45
The Cardiac Mitochondrion: Nexus of Stress
Christopher R. Baines ....................................... 61
The FoxO Family in Cardiac Function and Dysfunction
Sarah M. Ronnebaum and Cam Patterson ........................ 81
CELL PHYSIOLOGY
David E. Clapham, Associate and Section Editor
Chloride Channels: Often Enigmatic, Rarely Predictable
Charity Duran, Christopher H. Thompson, Qinghuan Xiao,
and H. Criss Hartzell ....................................... 95
ECOLOGICAL, EVOLUTIONARY, AND COMPARATIVE PHYSIOLOGY
Martin E. Feder, Section Editor
Physiology and Global Climate Change
Martin E. Feder ............................................ 123
Living in the Now: Physiological Mechanisms to Tolerate
a Rapidly Changing Environment
Gretchen E. Hofmann and Anne E. Todgham .................... 127
Light, Time, and the Physiology of Biotic Response to Rapid
Climate Change in Animals
William E. Bradshaw and Christina M. Holzapfel ............. 147
Locomotion in Response to Shifting Climate Zones: Not So
Fast
Martin E. Feder, Theodore Garland, Jr., James H. Marden,
and Anthony J. Zera ........................................ 167
ENDOCRINOLOGY
Holly A. Ingraham, Section Editor
Genomic Analyses of Hormone Signaling and Gene Regulation
Edwin Cheung and W. Lee Kraus .............................. 191
Macrophages, Inflammation, and Insulin Resistance
Jerrold M. Olefsky and Christopher K. Glass ................ 219
Structural Overview of the Nuclear Receptor Superfamily:
Insights into Physiology and Therapeutics
Pengxiang Huang, Vikas Chandra, and Fraydoon Rastinejad .... 247
GASTROINTESTINAL PHYSIOLOGY
James M. Anderson, Section Editor
Apical Recycling of the Gastric Parietal Cell H,K-ATPase
John G. Forte and Lixin Zhu ................................ 273
Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea
Henry J. Binder ............................................ 297
The Biogenesis of Chylomicrons
Charles M. Mansbach and Shadab A. Siddiqi .................. 315
NEUROPHYSIOLOGY
Roger Nicoll, Section Editor
Integrated Brain Circuits: Astrocytic Networks Modulate
Neuronal Activity and Behavior
Michael M. Halassa and Philip G. Haydon .................... 335
RENAL AND ELECTROLYTE PHYSIOLOGY
Gerhard H. Giebisch, Section Editor
Cellular Maintenance and Repair of the Kidney
Jian-Kan Guo and Lloyd G. Cantley .......................... 357
Intrarenal Purinergic Signaling in the Control of Renal
Tubular Transport
Helle A. Praetorius and Jens Leipziger ..................... 377
The Physiological Significance of the Cardiotonic Steroid /
Ouabain-Binding Site of the Na,K-ATPase
Jerry В. Lingrel ........................................... 395
RESPIRATORY PHYSIOLOGY
Richard С. Boucher, Jr., Section Editor
Inducible Innate Resistance of Lung Epithelium to Infection
Scott E. Evans, Yi Xu, Michael J. Tuvim, and Burton
F. Dickey .................................................. 413
It's Not All Smooth Muscle: Non- Smooth -Muscle Elements in
Control of Resistance to Airflow
Ynuk Bossé, Erik P. Riesenfeld, Peter D. Paré, and
Charles G. Irvin ........................................... 437
Regulation of Endothelial Permeability via Paracellular and
Transcellular Transport Pathways
Yulia Komarova andAsrar B. Malik ........................... 463
TH17 Cells in Asthma and COPD
John F. Alcorn, Christopher R. Crowe, and Jay K. Kolls ..... 495
SPECIAL TOPIC, CELLULAR AND MOLECULAR MECHANISMS OF
CIRCADIAN CLOCKS IN ANIMALS
Joseph S. Takahashi, Special Topic Editor
The Mammalian Orcadian Timing System: Organization and
Coordination of Central and Peripheral Clocks
Charna Dibner, Ueli Schibler, and Urs Albrecht ............... 517
Suprachiasmatic Nucleus: Cell Autonomy and Network
Properties
David K. Welsh, Joseph S. Takahashi, and Steve A. Kay ...... 551
Systems Biology of Mammalian Circadian Clocks
Hideki Ukai and Hiroki R. Ueda ............................. 579
Circadian Organization of Behavior and Physiology in
Drosophila
Ravi Allada and Brian Y. Chung ............................. 605
Mammalian Per-Arnt-Sim Proteins in Environmental Adaptation
Brian E. Mcintosh, John B. Hogenesch, and Christopher
A. Bradfield ............................................... 625
Indexes
Cumulative Index of Contributing Authors, Volumes 68-72 ....... 647
Cumulative Index of Chapter Titles, Volumes 68-72 ............. 650
Errata
An online log of corrections to Annual Review of Physiology
articles may be found at
http://physiol.annualreviews.org/errata.shtml
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